Drostanolone propionate: main effects and features to use

Chemical structure

Drostanolone dipropionate – anabolic (known as dromostanolone) – Changes dihydrotestosterone. It differs by the addition of a methyl group at position 2alpha, which affects the strength increase anabolic steroid, increasing resistance to metabolism enzyme 3a-hydroxysteroid dehydrogenase in muscle tissue (2alpha, 5a, 17 beta) -17-Hydroxy-2-metilandrostan-3-one formula C20H32O2 . Drostanolone propionate – a modified form of drostanolone with a propionate ester attached via the 17-beta hydroxyl group. Unlike free steroids esterified less polar therefore not rapidly absorbed from the injection site. Once in the bloodstream, and the ether is cleaved by blood moves freely drostanolone. The development objective was to increase the esterified steroids during therapeutic effect after entering, to inject less frequently when compared with taking steroids available. The half-life at drostanolone propionate is about two days after injection. The medical literature drostanolone described as a powerful anabolic agent with anti-estrogenic properties. In spite of this, many scientists admit that the anabolic properties drostanola rather moderate when compared with similar drugs. It is widely used by athletes who are on a diet, as well as dealing with speed and power sports in which it is necessary to influence the property of the increase in muscle mass and strength, reducing body fat, while having no serious adverse qualities.

Historical reference

Described drostanolone propionate was in 1959. Its development was engaged in the company Syntex, along with oksimetalonom metildrostanolonom and, despite this, in pharmacies drug appeared only 10 years later. Between the companies Lilly and Syntex was agreed on the joint application development. Drostanolone propionate first sold in the United States, calling it drolban and the second spread the same drug in other markets. In Belgium, it was called Masteron, in the UK and Bulgaria – Masters in Spain – metormon, France – permastril, Japan – mastisol in the GDR – masterid. The US by the Food and Drug Administration approved the drostanolone propionate as a drug for the treatment of inoperable breast cancer in women in menopause. That is it and used in the world. There are reports in the medical literature that drostanolone propionate gave less virilization, when compared with testosterone propionate. Despite this, in the book there is a mention that vyskokie dose (300 mg in 7 days) caused virilization. Drostanolone widely used athletes in the 70-80’s, but in medicine it was used with some restrictions. When there were other methods of treatment of breast cancer, produce drostanolone become smaller, and then completely stopped, it gradually disappeared from the market.

pharmachologic effect

It reduces the production of follicle stimulating hormone and lyuteotropnogo. Drostanolone dipropionate has androgenic (when compared to testosterone propionate, then expressed less) and anabolic (expressed more than testosterone propionate) effect. It has anti-tumor effect in patients with cancer of the thymus gland, even in the presence of metastases, and patients with suppressed ovarian function due to irradiation, androgenic drugs or undergoing ovariektomii.Effekt exercise more during a bilateral ovariectomy. Has an anabolic effect, this results in the stimulation of protein synthesis, reducing fat deposition, the delay in the human body required for protein synthesis, potassium, phosphorus, sulfur, enhancing fixation of bone calcium, and increasing muscle mass. If there is sufficient supply of protein stimulates the production of erythropoietin.

The steroid profile drostanolone dipropionate

  • Active substance is 2-3 days
  • Classification: Steroid anabolic / androgenic origin
  • Application method: by injection
  • Dosage: Men 300-500mg for 7 days; Women 25-50mg for 7 days
  • Acne: Yes
  • Water Retention: No
  • High blood pressure: Occasionally
  • Hepatotoxicity: No
  • Aromatase: No
  • Progestogenic activity: No
  • DHT (dihydrotestosterone) conversion: None
  • Decrease HPTA function (testosterone production): yes
  • Anabolic activity (25-40%); Androgenic activity (62-130%)
  • Detection time – 14 days (approximately, since doping commission is constantly looking for new and improved methods for detection of banned substances, as this depends on the athlete to use the drug, whether it uses phenobarbital and furosemide to accelerate the withdrawal of the drug)

456Effects drostanolone dipropionate

  1. It gives a good effect when used for drying
  2. It affects the density of muscle
  3. It affects performance increase strength, reducing body fat, gives a good effect when used before the competition

Application drostanolone dipropionate:

Reception (for men):

The recommended dose is equal to 300-500 mg / 7 days, usually, on the third day, or one by one. Course duration 6 (8) -10 (12) weeks. Usually combined with nandrolone decanoate or boldenone undesilinatom, it affects the increase in muscle mass, at the same time not unduly delaying the water. In order to set its weight combined with injectable testosterone, it affects the growth of muscle mass without excess “water” that would accumulate if taken with other drugs. Drostanolone is used and the purpose of “drying”. It is combined with other non-aromatizing agents, for example, stanozolol, Primobolan, trenbolone or oxandrolone, and it helps to keep the muscle on a diet and sgonke.

Reception (for women):

Women are advised to take the drug is not due to high androgen.

The medical use of drostanolone administered 100mg x 3 p in 7 days, 2-3 months, followed to evaluate the result. Signs of virilization were highly significant at this dose. In order to improve physique drug taking 25-50mg of 7 days, for 4-6 weeks. Also, it should be noted in connection with a speed of propionate ester preparation is necessary to prick every second or third day.

Side effects drostanolone dipropionate

Drostanolone does not aromatize and does not have estrogenic activity. Anti-estrogens are not needed, even sensitive people will not notice the symptoms of gynecomastia. As a general rule, estrogen retains water, but taking this steroid increases quality mass without excess liquid. In this regard, the drug was well used to the “drying”, it was then the main problem – it’s water retention and fat. As a non-aromatizing a derivative of dihydrotestosterone, drostanolone may exhibit some anti-estrogenic effect, thus competing with other substances for binding to aromatase.

Despite the fact that drostanolone is classified as an anabolic, androgenic side effects may be present. High doses of the drug can cause increased oiliness of the skin, acne, hair growth on the body and face. Anabolic steroids can probably worsen hair loss male pattern. Women should be reminded of the possible effects of AAS virilizuyuschih (deepening of the voice, irregular periods, change in skin texture, facial hair growth, and enlargement of the clitoris). Drostanolone does not react with 5a-reductase and androgen will change the parallel use of finasteride or dutasteride. While that is a steroid with low androgenic activity, its threshold androgenic side effects is much greater than that of testosterone, methandrostenolone and fluoxymesterone.

Drostanolone – not alkylated at position 17-alpha formulation in this regard it has no hepatotoxic properties.

AAS can have a detrimental effect on blood cholesterol. This may be a decrease in the level of “good” HDL cholesterol, shifting the balance towards the risk of atherosclerosis. Relative impact AAS lipids depends on the dose, route of administration, the type and level of steroid resistance hepatic metabolism. Drostanolone have a more pronounced negative effect on the control of hepatic cholesterol than testosterone and nandrolone, since it nearomatiziruyuscheyasya structure, but the effect is less than that of 17-alpha-alkylated products. AAS may adversely affect blood pressure and triglycerides, reduce endothelial relaxation of blood vessels, trigger ventricular hypertrophy, and it has the potential to increase the risk of cardiovascular disease and heart attack. To reduce the load on the cardiovascular system, it is advised to minimize the use of saturated fat, cholesterol, and simple carbohydrates during the course AAS. Recommend to use additives, such as fish oil, lipid Stabil and similar products.

All AAS doses needed to build muscle, suppress endogenous testosterone production. If you do not take testosterone stimulating substances, it will come to its normal level over 1-4 months after the course. It should be noted that prolonged hypogonadotrophic hypogonadism can develop secondary and it is likely that need medical intervention.

Indications for drug use drostanolone dipropionate

Breast cancer, including metastases in women with a menstrual cycle or stored at 5 years until menopause.

Contraindications to drug use drostanolone dipropionate

Do not take the people with the following diseases: hypersensitivity, acute liver disease, kidney disease, cardiovascular system (myocardial infarction, severe hypertension, hypertensive crisis), hypercalcemia, end-stage breast cancer.