Drostanolone propionate: estrogen and androgen action

Pharmacological group: anabolic / androgenic steroids

Androgen: 25-40

Anabolic: 62-130

Standard: Testosterone

Chemical name: 2alpha-methyl-androstan-3-one-17beta-ol 2alpha-methyl-dihydrotestosterone

Estrogenic Activity: none

Progesterone Activity: unknown (low)

Description

Drostanolone propionateinjecting anabolic steroid based dihydrotestosterone (DHT). It has a modified base DHT. 2-methyl group increases the anabolic properties of the drug and its effectiveness to promote the growth of muscle tissue, as compared with its unmethylated precursors. Drostanolone propionate is described in the literature as “steroid with potent anabolic and anti-estrogenic properties.” However, its anabolic properties properly called moderate, especially when compared with other drugs. The drug most frequently used by bodybuilders during a diet and athletes in speed sports, where it is prized for its ability to increase muscle mass and strength that is usually accompanied by a decrease in the level of fat and minimal side effects.

History

Drostanolone propionate was first described in 1959. Syntex Company has developed along with the drug commonly known steroids such as Anapolon and Metildrostanolon (superdrol), first described in the same time. About ten years later, drostanolone propionate begins to be used as a prescription drug. , Lilly entered into an agreement with Syntex separation of duties for certain research and development in exchange for the right to sell the results of this study. Lilly, thus gaining the right to sell drostanolone propionate in the United States under the brand name Drolban, and the company Syntex – in other markets. These products include, inter alia, in Belgium Masteron (SarvaSyntex) and Portugal (Cilag), Masteril in the UK and Bulgaria, and Metormon in Spain. Drostanolone propionate is also a member of such popular products as Permastril (Cassenne, France), Mastisol (Shionogi, Japan) and Masterid (Grunenthal, the German Democratic Republic). The US Department of quality control of food and drugs (FDA) approved drostanolone propionate for the treatment of inoperable breast cancer in postmenopausal women. This fact influenced the clinical indications for the drug in all international markets. The medical literature is often stated that drostanolone propionate has a much smaller effect virilization in comparison with equal doses of testosterone propionate, and is considered a good alternative to injection of testosterone to women. However, this dose level (300 mg weekly) is relatively high. Before the drug can appear mild symptoms of virilization, such as deepening of the voice, acne, facial hair growth, and clitoral enlargement. It is also noted that the effects of virilization sometimes occurs after a period of prolonged therapy. Very popular among athletes in the 1970s and 80s, drostanolone propionate and enjoyed limited success as a prescription drug. Manufacturers soon voluntarily stopped sales of the drug in different markets, which is probably due to the emergence of more effective treatments for breast cancer, as well as a gradual decline in popularity of steroids at this stage of treatment. One of the first drugs that ceased to exist on the market, was Drolban in the US is no longer available in the late 1980s. Soon it was followed Permastril and Metormon. The last remaining West preparation containing drostanolone propionate – drug Masteron from Belgium, disappeared from the market in the late 1990s. Drostanolone propionate is still in the US Pharmacopoeia and it is estimated that currently there are no legal obstacles to its implementation, although commercial rebirth Masteron as a prescription drug is highly unlikely.

How Supplied

Drostanolone propionate is no longer available as a prescription drug. During its production the drug was produced in the form of 1 ml and 2 ml vials and 10 ml vials containing 50 mg / ml or 100 mg / ml of the steroid in the oil.

Structural Features

Drostanolone (also known as dromostanolone) is a modified form of dihydrotestosterone. It is characterized by the introduction of a methyl group at carbon-2 (alpha), which significantly increases the anabolic steroid effect and enhances its stability to metabolism in the skeletal muscle tissues through the 3-hydroxysteroid dehydrogenase enzyme. Drostanolone propionate is a modified form of drostanolone, wherein the carboxylic acid (propionic acid) is attached to the 17-beta hydroxy group. Esterified steroids are less polar than the free steroid and slowly absorbed from the injection site. Once in the blood, the air is removed, leaving the free (active) drostanolone. Esterified steroids are designed to prolong the therapeutic effect after the reception, which allows you to inject less frequently than with the free (non-esterified) steroids. The half-life drostanolone propionate lasts about two days after the injection.

Side effects Masteron (estrogen)

Drostanolone is not flavored, nor is markedly estrogenic substance. In the application of this steroid it is not necessary to use an anti-estrogen and gynecomastia are usually not evident even in very sensitive individuals. Drostanolone provides user-dried and “quality” in the form of body, without excess subcutaneous fluid retention. This makes it a favorable steroid to use during drying, when water and fat retention are major challenges. As nearomatiziruemoe DHT derivative, drostanolone may have anti-estrogenic effect, and compete with other (flavoring) substrates in the binding of the enzyme aromatase.

84Side effects Masteron (androgens)

Although the drug is classified as an anabolic steroid, when the reception is still possible manifestation androgenic side effects, especially at higher doses. It effects may include: increased fat content of the skin, acne and hair growth on the body / face. Anabolic / androgenic steroids may also aggravate male pattern baldness. Women also need to be warned of the potential virilizing effects of anabolic / androgenic steroids. These effects may include deepening of the voice, menstrual irregularities, changes in skin texture, facial hair growth, and clitoral enlargement. Drostanolone – steroid with relatively low androgenic activity binding in tissues, and the threshold for strong androgenic side effects, it has a relatively higher as compared with more androgenic agents such as testosterone or fluoxymesterone methandrostenolone. Note that drostanolone does not affect the enzyme 5-alpha-reductase, so its relative androgen dependent on the simultaneous use of finasteride or dutasteride.

Side effects Masteron (hepatotoxicity)

Drostanolone is not c17-alpha alkylated substance and has no known hepatotoxic properties. Toxicity in the liver is unlikely.

Side effects Masteron (cardiovascular)

Anabolic / androgenic steroids can have deleterious effects on cholesterol levels, which includes a tendency to reduce the levels of HDL (good) cholesterol and increase LDL (bad cholesterol), HDL and biasing the ratio of LDL in the direction of fostering a greater risk of atherosclerosis. The relative impact of anabolic / androgenic steroids on serum lipids depends on the dose, routes of administration (oral or injection), a steroid-type (flavoring or less) and the level of resistance to metabolism in the liver. Drostanolone should have a stronger negative effect on hepatic cholesterol than testosterone or nandrolone, due to its non-aromatizing nature, but weaker effect than a 17-alpha alkylated steroids. Anabolic / androgenic steroids may also adversely affect blood pressure and triglycerides, reduce endothelial relaxation, and support left ventricular hypertrophy, which could potentially increase the risk of cardiovascular disease and myocardial infarction. In order to reduce the risk of cardiovascular deformations, it is recommended to perform active exercises and cardio minimize the consumption of saturated fat, cholesterol, and simple carbohydrates at all times during the active use of AAS. It is also recommended additional intake of fish oil (4 g per day) and a natural cholesterol / antioxidants such as Lipid Stabil or products with comparable ingredients.

Side effects Masteron (suppression of testosterone)

All anabolic / androgenic steroids when taken in doses sufficient to promote muscle growth, inhibit the production of endogenous testosterone. Without the intervention of testosterone stimulating substances, testosterone levels should return to normal within 1-4 months of treatment. Note that secondary to steroids can develop a long hypogonadotropic hypogonadism requiring medical intervention. The above listed side effects is not complete.

Course Masteron (men)

Drostanolone propionate has not been approved by the FDA for use in men. There are no guidelines for his appointment. In order to improve the physique or performance enhancing drug is usually administered by injection three times per week. Weekly dose is generally 200-400 mg, and is received within 6-12 weeks. This dose is sufficient for a measurable increase in muscle mass and strength. To enhance the effect Drostanolone propionate is often combined with other steroids such as injectable anabolic Deca ® (nandrolone decanoate) or Equipoise ® (boldenone undecylenate), providing muscle growth without excessive water retention. For muscle building steroid is often combined with injectable testosterone. Result – muscle growth and a lower level of water retention and other estrogenic side effects than when using these steroids alone (as a rule, at higher doses). Masteron is most often used during the drying process. It is often combined with other flavoring not steroids such as Winstrol ®, Primobolan ®, Parabolan or Anavar, which helps maintain muscle mass and graft promotes fat loss, during a period which can be very catabolic without steroids.

Course Masteron (women)

Masteron women used a dose of 100 mg three times per week. Before we evaluate the effectiveness of a substance, you should take it at least 8-12 weeks. If successful, the drug can still be used as long as is necessary to obtain satisfactory results. Please note that virilization symptoms often occur even at the recommended dosage. When used in order to improve productivity or body, most often the dose of 50 mg per week for 4-6 weeks. At a dose of 100 mg per week or less masculinizing effects occur rarely. Note that because of the short nature of action ether propionate total weekly dose is usually divided into smaller injection every two or three days.

Availability:

The original Masteron is already available on the black market drug. In Europe, its production has long been discontinued. The old parties have not circulate, which means that there is no legitimate source for marketing a product called Masteron anywhere else. Other laws pharmaceutical brands are almost nonexistent. There is a version of drostanolone sold in Myanmar called Dromostan company XELOX. The preparation contains drostanolone instead drostanolone propionate. Although the drug is not passed laboratory tests, this company is legitimate and hopefully produces a legal product. If so, then this product buy liothyronine sodium is the second real Drostanolone, sold currently. Due to the absence of air, injection best done every 2 days, slightly more often than when using Masteron (3-4 times). In addition to the above, at present there are many clandestine laboratories drostanolone propionate. Make sure you understand the risks involved in the clandestine purchase of products. Risks can include more than just the loss of money as underground products are often not produced in a sterile environment.